Underpinning the Potential of Herpes Simplex Virus (HSV) in CNS Gene Therapies
Time: 2:15 pm
day: POST-CONFERENCE DELIVERY FOCUS DAY
Details:
- Methods for complete HSV vector gene silencing to achieve vector safety and prevent the induction of inflammatory processes
- Methods to create 40kb of space for very large or multiple transgenes and the development of engineering methods for transgene cassette design and genomic positioning that overcome transgene silencing and provide for regulated, long-term transgene expression in neurons
- Vector production for application to animal model testing. This gene delivery technology will be broadly useful for the treatment of neurological diseases that require large or multiple genetic interventions
