Systemic Administration of Novel Engineered AAV Capsids Facilitates Enhanced Transgene Expression in the Macaque CNS
Time: 12:00 pm
day: Day Two: Track B AM
Details:
- Utilizing an mRNA-based selection strategy to select novel capsids with enhanced tropism for the CNS after intravenous delivery
- We identified the novel PAL family of capsids which have enhanced CNS targeting and reduced liver tropism in 2 year old cynomolgus macaques
- We found that a diverse set of capsids potent in the murine CNS were universally ineffective in macaques
