A High-Throughput Automated Platform for Discovery of CNS Penetrant Capsids in NHPs

Time: 1:30 pm
day: Post-Conference Delivery Day


  • We redesigned the workflow for capsid engineering from the ground up to leverage automated systems that enable greater throughput and data quality
  • Initial capsids emerging from these efforts have now been characterized as single variants, showing >10% neuronal transduction and expression in certain NHP brain regions following IV delivery
  • Further optimized variants are being generated via novel mutagenesis strategies paired with
    in vitro and in vivo functional characterization